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                          September 2, 2021

       Kenneth A. Berlin
       President and Chief Executive Officer
       Advaxis, Inc.
       9 Deer Park Drive, Suite K-1
       Monmouth Junction, NJ 08852

                                                        Re: Advaxis, Inc.
                                                            Registration
Statement on Form S-4
                                                            Filed August 25,
2021
                                                            File No. 333-259065

       Dear Mr. Berlin:

              This is to advise you that we have not reviewed and will not
review your registration
       statement.

               Please refer to Rules 460 and 461 regarding requests for
acceleration. We remind you
       that the company and its management are responsible for the accuracy and
adequacy of their
       disclosures, notwithstanding any review, comments, action or absence of
action by the staff.

                                                        Please contact David
Gessert at 202-551-2326 with any questions.




                          Sincerely,


                          Division of Corporation Finance

                          Office of Life Sciences