UNITED
STATES
SECURITIES
AND EXCHANGE COMMISSION
Washington,
D.C. 20549
FORM
8-K
CURRENT
REPORT
Pursuant
to Section 13 or 15(d)
of
the Securities Exchange Act of 1934
September
22, 2008
(Date
of
Earliest Event Reported)
Advaxis,
Inc.
(Exact
name of registrant as specified in its charter)
Delaware
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00028489
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02-0563870
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(State
or other jurisdiction
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(Commission
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(IRS
Employer
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of
incorporation)
|
File
Number)
|
Identification
No.)
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Technology
Center of New Jersey
675
Rt. 1, Suite B113
North
Brunswick, N.J. 08902
(Address
of principal executive offices)
(732)
545-1590 (Registrant’s
telephone number, including area code)
|
(Former
name or former address, if changed since last report.)
|
Check
the
appropriate box below if the Form 8-K filing is intended to simultaneously
satisfy the filing obligation of the registrant under any of the following
provisions (see General Instruction A.2. below):
o
Written communications
pursuant to Rule 425 under the Securities Act (17 CFR 230.425)
o
Soliciting material pursuant to Rule
14a-12 under the Exchange Act (17 CFR 240.14a-12)
o
Pre-commencement communications pursuant
to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))
o
Pre-commencement communications pursuant
to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))
Item
1.01 Entry into a Material Definitive Agreement.
On
September 22, 2008, Advaxis, Inc. (the “Company”) entered into a Note Purchase
Agreement (the “Agreement”) with the Company’s Chief Executive Officer, Thomas
Moore, pursuant to which the Company agreed to sell to Mr. Moore, from time
to
time, one or more senior promissory notes (each a “Note” and collectively the
“Notes”) with an aggregate principal amount of up to $800,000.
The
Agreement was reviewed and recommended to the Company’s Board of Directors (the
“Board”) by a special committee of the Board and was approved by a majority of
the disinterested members of the Board. The Note or Notes, if and when issued,
will bear interest at a rate of 12% per annum, compounded quarterly, and will
be
due and payable on the earlier of the close of the Company’s next equity
financing resulting in gross proceeds to the Company of at least $5,000,000
(the
“Subsequent Equity Raise”) or February 15, 2009 (the “Maturity Date”). The
Note(s) may be prepaid in whole or in part at the option of the Company without
penalty at any time prior to the Maturity Date.
In
consideration of Mr. Moore’s agreement to purchase the Notes, the Company agreed
that concurrently with the Subsequent Equity Raise, the Company will issue
to
Mr. Moore a warrant to purchase the Company’s common stock, which will entitle
Mr. Moore to purchase a number of shares of the Company’s common stock equal to
one share per $1.00 invested by Mr. Moore in the purchase of one or more Notes.
Such warrant would contain the same terms and conditions as warrants issued
to
investors in the Subsequent Equity Raise.
To
date and pursuant to the Agreement, Mr. Moore has
leant the Company $235,000.
The
Agreement and Form of Note are attached as Exhibits 10.1 and 4.1, respectively,
to this Report on Form 8-K and are incorporated herein by
reference.
Item
2.03 Creation of a Direct Financial Obligation or an Obligation under an
Off-Balance Sheet Arrangement of a Registrant.
The
information set forth in Item 1.01 of this report is incorporated herein by
reference.
Item
8.01 Other Events
On
September 30, 2008, the Registrant issued a press announcing the terms of the
Agreement. A copy of the press release is attached as Exhibit 99.1 to this
Report on Form 8-K and are incorporated herein by reference.
Item
9.01. Financial Statements and Exhibits.
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4.1
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Form
of Senior Promissory Note.
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10.1
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Note
Purchase Agreement, between Advaxis, Inc. and Thomas A. Moore, dated
September 22, 2008.
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99.1
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Press
release of Advaxis, Inc., dated September 30,
2008.
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SIGNATURE
Pursuant
to the requirements of the Securities Exchange Act of 1934, Registrant has
duly
caused this report to be signed on its behalf by the undersigned hereunto duly
authorized.
Dated:
September 30, 2008
Advaxis,
Inc.
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By:
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/s/
Thomas A. Moore
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Name:
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Thomas
A. Moore
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Title:
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Chief
Executive Officer
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EXHIBIT
4.1
$[____________]
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[______
__], 20[__]
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ADVAXIS,
INC.
FORM
OF SENIOR PROMISSORY NOTE
Maturity
Date: February 15, 2009
THIS
SENIOR PROMISSORY NOTE HAS NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF
1933,
AS AMENDED (THE “SECURITIES
ACT”),
OR
ANY STATE SECURITIES LAW. NO SALE, TRANSFER, PLEDGE OR ASSIGNMENT OF THIS SENIOR
PROMISSORY NOTE SHALL BE VALID OR EFFECTIVE UNLESS (A) SUCH TRANSFER IS MADE
PURSUANT TO AN EFFECTIVE REGISTRATION STATEMENT UNDER THE SECURITIES ACT AND
IN
COMPLIANCE WITH ANY APPLICABLE STATE SECURITIES LAW, OR (B) SUCH TRANSFER IS
MADE PURSUANT TO AN EXEMPTION FROM THE REGISTRATION REQUIREMENTS OF THE
SECURITIES ACT AND OF ANY APPLICABLE STATE SECURITIES LAW.
FOR
VALUE
RECEIVED, Advaxis, Inc., a Delaware corporation (the “Company”),
promises to pay to Thomas A. Moore, the joint registered holder or registered
assigns hereof (the “Holder”),
the
principal amount of [AMOUNT IN WORDS] ($_________), payable on February, 2009
(the “Maturity
Date”),
or
such earlier date as required by Section 2 hereof, together with interest on
the
outstanding principal amount of this Note, accruing at the rate of twelve
percent (12%) per annum, compounded quarterly, commencing on the date hereof,
subject to Section 2 hereof. All interest shall be calculated on the basis
of a
360-day year counting the actual days elapsed. Accrued interest shall be payable
upon the maturity of this Note and at the time of any prepayment, as provided
below. Capitalized terms used but not defined herein shall have the meanings
ascribed to such terms in the Note Purchase Agreement, dated as of the date
hereof, between the Company and the Holder (the “Note
Purchase Agreement”).
1. Payments
and Prepayments.
(a) Payments
of principal and interest on this Note shall be made at the Holder’s address as
set forth in the Note Purchase Agreement, or such other place or places as
may
be specified by the Holder of this Note in a written notice to the
Company.
(b)
Payments
of principal and interest on this Note shall be made in lawful money of the
United States of America by wire transfer of immediately available funds so
as
to be received by the Holder on the due date of such payment.
(c) If
any
payment on this Note becomes due and payable on a Saturday, Sunday or other
day
on which commercial banks in New York, New York are authorized or required
by
law to close, the maturity thereof shall be extended to the next succeeding
business day and, with respect to payments of principal, interest thereon shall
be payable during such extension.
(d) This
Note
may be prepaid in whole or in part at the option of the Company at any time
prior to the Maturity Date. Accrued interest on any amount of principal prepaid
shall be due and payable at the time of such prepayment.
2. Events
of Default.
In the
event that any one or more of the following occurs (each, an “Event
of Default”):
(i) the
Company defaults in the payment of principal on the date due or defaults in
the
payment of interest required to be made on this Note and such default in the
payment of interest shall continue for a period of ten (10) days;
(ii) the
Company ceases all or substantially all of its business activities other than
by
reason of natural disaster; material fire or other casualty; quarantine or
epidemic or other cause beyond the Company’s reasonable control, and the Company
does not resume all or substantially all of its business activities within
sixty
(60) days thereafter;
(iii) the
Company hereafter makes an assignment for the benefit of creditors, or files
a
petition in bankruptcy as to itself, is adjudicated insolvent or bankrupt,
petitions a receiver of or any trustee for the Company or any substantial part
of the property of the Company under any bankruptcy, reorganization,
arrangement, readjustment of debt, dissolution or liquidation law or statute
of
any jurisdiction, whether or not hereafter in effect; or if there is hereafter
commenced against the Company any such proceeding and an order approving the
petition is entered or such proceeding remains undismissed for a period of
sixty
(60) days, or the Company by any act or omission to act indicates its consent
to
the approval of or acquiescence in any such proceeding or the appointment of
any
receiver of, or trustee for, the Company or any substantial part of its
properties, or suffers any such receivership or trusteeship to continue
undischarged for a period of sixty (60) days;
then,
and
in any such event, and at any time thereafter, if such event shall then be
continuing, the Holder of this Note may (x) declare this Note (including the
Premium) immediately due and payable, whereupon the same shall be immediately
due and payable without presentment, demand, protest or other notice of any
kind, and/or (y) pursue any and all available remedies against the Company
for
the collection of outstanding principal and interest under this Note. Upon
the
occurrence and during the continuance of any Event of Default, the interest
rate
per annum set forth on the first page hereof shall be increased by 0.1% per
day
until the cure of such Event of Default; provided,
that in
no event shall such interest rate be increased above the maximum amount
permitted by applicable law.
3. Senior
Note.
This
Note, along with the other Notes that may be issued by the Company to the
Holder, shall be senior in right of payment to and shall be senior to all other
indebtedness of the Company.
4. Miscellaneous.
(a) Upon
receipt of evidence reasonably satisfactory to the Company of the loss, theft,
destruction or mutilation of this Note and of a letter of indemnity reasonably
satisfactory to the Company, and upon reimbursement to the Company of all
reasonable expenses incident thereto, and upon surrender or cancellation of
this
Note, if mutilated, the Company will make and deliver a new Note of like tenor
in lieu of such lost, stolen, destroyed or mutilated Note.
(b) Except
as
otherwise expressly provided in this Note, the Company hereby waives diligence,
demand, presentment for payment, protest, dishonor, nonpayment, default, and
notice of any and all of the foregoing.
(c) Neither
any provision of this Note nor any performance hereunder may be amended or
waived orally, but only by an agreement in writing and signed by the party
against whom enforcement of any waiver, change, modification or discharge is
sought. All rights and remedies conferred upon the Holder under this Note shall
be cumulative and may be exercised singly or concurrently.
(d) No
course
of dealing between the Company and the Holder, or any failure or delay on the
part of the Holder in exercising any rights or remedies, or any single or
partial exercise of any rights or remedies, shall operate as a waiver or
preclude the exercise of any other rights or remedies available to the
Holder.
(e) In
the
event that the Holder shall, during the continuance of an Event of Default,
turn
this Note over to an attorney for collection, the Company shall further be
liable for and shall pay to the Holder all collection costs and expenses
incurred by the Holder, including reasonable attorneys’ fees and expenses; and
the Holder may take judgment for all such amounts in addition to all other
sums
due hereunder.
(f) This
Note
shall be governed by and construed in accordance with the laws of the State
of
Delaware, without regard to any principles of conflict of laws.
[Signature
Page Follows]
IN
WITNESS WHEREOF, the Company has duly caused this Note to be signed on its
behalf, in its corporate name and by its duly authorized officer as of the
date
and year first written above.
EXHIBIT
10.1
ADVAXIS,
INC.
NOTE
PURCHASE AGREEMENT
THIS
NOTE
PURCHASE AGREEMENT
(this “Agreement”)
is
made as of the 22 day of September, 2008, by and between Advaxis, Inc., a
Delaware corporation (the “Company”),
and
Thomas A. Moore, an individual (the “Investor”).
Recitals
The
Investor is the Chief Executive Officer and a member of the Board of Directors
of the Company.
The
Company desires to issue and sell, and the Investor desires to purchase, upon
the Company’s demand upon 10 business days’ notice, one or more senior
promissory notes with an aggregate principal amount of up to eight hundred
thousand dollars ($800,000.00) in substantially the form attached to this
Agreement as Exhibit
4.1
(each, a
“Note”).
The
Company and the Investor desire that, upon the consummation of a future equity
financing by the Company, the Company issue to the Investor warrants to purchase
the Company’s common stock as described herein.
The
Company and the Investor desire to set forth certain agreements and certain
terms and conditions regarding the sale and purchase of the Notes.
Agreement
NOW,
THEREFORE,
in
consideration of the foregoing premises, the respective representations,
warranties and covenants contained herein, and certain other good and valuable
consideration, the receipt and sufficiency of which are hereby acknowledged,
the
parties agree as follows:
1. PURCHASE
AND SALE OF THE NOTES.
1.1 Purchase
and Sale of the Notes.
Subject
to the terms and conditions of this Agreement and in reliance on the
representations and warranties set forth in this Agreement, following the
delivery by the Company to the Investor of a written notice (each, a
“Demand
Notice”)
in
accordance with Section 6.7, the Company agrees to issue, sell and deliver
to
the Investor at the Closing (as defined below), and the Investor agrees to
purchase from the Company at the Closing, a Note in the principal amount set
forth in the Demand Notice. The Company shall be entitled to deliver one or
more
Demand Notices to the Investor for an aggregate principal amount of no more
than
eight hundred thousand dollars ($800,000.00).
1.2 Closing.
The
closing and funding of the purchase and sale of each Note (each, a “Closing”)
shall
take place at the offices of Greenberg Traurig, LLP, 200 Park Avenue, New York,
New York 10166 no more than ten (10) business days following the date of each
Demand Notice as determined in accordance with Section 6.7, or at such other
time and place as the Company and the Investor mutually agree upon in
writing.
2. WARRANTS.
In
consideration of the Investor’s agreement to purchase Notes, the Company agrees
that, concurrently with the consummation of the Company’s next equity financing
resulting in gross proceeds to the Company of at least $5,000,000, the Company
shall issue to the Investor a warrant to purchase the Company’s common stock
(the “Warrant”).
The
Warrant shall entitle the Investor to purchase a number of shares of the
Company’s common stock equal to one share per $1.00 invested by the Investor in
the purchase of one or more Notes, which share amount shall be subject to
appropriate adjustment for stock splits, stock dividends and similar events.
The
Warrant shall otherwise be on the same terms, including but not limited to
exercise price, mechanics of execution and registration rights, applicable
to
warrants issued to the new investors in such equity financing. In the event
that
such equity financing does not involve the issuance of warrants, then the
Warrant shall have an exercise price equal to the effective purchase price
per
share paid by investors in such equity financing, and the Investor shall receive
registration rights with respect to shares of the Company’s common stock
underlying the Warrant on the same terms as securities purchased by such
investors.
3. REPRESENTATIONS
AND WARRANTIES OF THE COMPANY.
As
of
each Closing, the Company hereby represents and warrants to the Investor as
follows:
3.1 Organization
and Standing.
The
Company is a corporation duly organized and validly existing under, and by
virtue of, the laws of the State of Delaware and is in good standing under
such
laws. The Company has requisite corporate power and authority to own and operate
its properties and assets, and to carry on its business as presently conducted.
The Company is duly qualified to do business in each jurisdiction in which
the
failure to be so qualified would have a material adverse effect on the Company’s
business.
3.2 Corporate
Power.
The
Company has all requisite legal and corporate power and authority to execute
and
deliver this Agreement and each Note to be dated the date of each Closing
(collectively, the “Transaction
Agreements”)
and to
carry out and perform its obligations under the terms of each of the Transaction
Agreements.
3.3 Authorization.
All
corporate action on the part of the Company, its officers and directors
necessary for the authorization, execution, delivery and performance of the
Transaction Agreements and the performance of all obligations of the Company
hereunder and thereunder has been taken or will be taken prior to each Closing.
Each Transaction Agreement, when executed and delivered by the Company, shall
constitute a valid and binding obligation of the Company, enforceable in
accordance with its respective terms, except as limited by applicable
bankruptcy, insolvency, reorganization, moratorium and other laws of general
application affecting enforcement of creditors’ rights generally and as limited
by laws relating to the availability of specific performance, injunctive relief
or other equitable remedies.
3.4 Offering.
Subject
to truth and accuracy of the Investor’s representations in Section
4
hereof,
the offer, sale and issuance of the Notes constitute transactions exempt from
the registration requirements of Section 5 of the Securities Act of 1933,
as amended (the “Securities
Act”),
and
in compliance with applicable state securities laws.
4. REPRESENTATIONS
AND WARRANTIES OF THE INVESTOR.
The
Investor represents and warrants to the Company as of the time of each Closing
as follows:
4.1 Authorization.
This
Agreement, when executed and delivered by the Investor shall constitute a valid
and binding obligation of the Investor, enforceable in accordance with its
terms, except as limited by applicable bankruptcy, insolvency, reorganization,
moratorium and other laws of general application affecting enforcement of
creditors’ rights generally and as limited by laws relating to the availability
of specific performance, injunctive relief or other equitable
remedies.
4.2 Purchase
Entirely for Own Account.
This
Agreement is made with the Investor in reliance upon the Investor’s
representation to the Company, which by the Investor’s execution of this
Agreement the Investor hereby confirms, that each Note will be acquired for
investment for the Investor’s own account, not as a nominee or agent, and not
with a view to the resale or distribution of any part thereof, and that the
Investor has no present intention of selling, granting any participation in,
or
otherwise distributing the same. By executing this Agreement, the Investor
further represents that the Investor does not have any contract, undertaking,
agreement or arrangement with any person to sell, transfer or grant
participations to such person or to any third person with respect to any
Note.
4.3 Disclosure
of Information.
The
Investor believes he has received all the information he considers necessary
or
appropriate for deciding whether to purchase Notes. The Investor further
represents that he has had an opportunity to ask questions and receive answers
from the Company regarding the terms and conditions of the offering of the
Notes
and the business, properties, prospects and financial condition of the
Company.
4.4 Accredited
Investor.
The
Investor is an “accredited investor” within the meaning of Rule 501 of
Regulation D of the Securities Act.
4.5 Restricted
Securities.
The
Investor acknowledges that the Notes may have to be held indefinitely, and
may
not be sold or transferred, unless subsequently registered under the Securities
Act or unless an exemption from such registration is available. The Investor
is
aware of the provisions of Rule 144 promulgated under the Securities Act which
permits limited resale of securities purchased in a private placement subject
to
the satisfaction of certain conditions.
5. LEGENDS.
The
certificates representing each Note shall be endorsed with a legend
substantially as follows:
THIS
SENIOR PROMISSORY NOTE HAS NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF
1933,
AS AMENDED (THE “SECURITIES
ACT”),
OR
ANY STATE SECURITIES LAW. NO SALE, TRANSFER, PLEDGE OR ASSIGNMENT OF THIS SENIOR
PROMISSORY NOTE SHALL BE VALID OR EFFECTIVE UNLESS (A) SUCH TRANSFER IS MADE
PURSUANT TO AN EFFECTIVE REGISTRATION STATEMENT UNDER THE SECURITIES ACT AND
IN
COMPLIANCE WITH ANY APPLICABLE STATE SECURITIES LAW, OR (B) SUCH TRANSFER IS
MADE PURSUANT TO AN EXEMPTION FROM THE REGISTRATION REQUIREMENTS OF THE
SECURITIES ACT AND OF ANY APPLICABLE STATE SECURITIES LAW.
6. MISCELLANEOUS.
6.1 Waivers
and Amendments.
With
the written consent of the Company and the Investor, the obligations of the
Company and the rights of the Investor under this Agreement may be waived
(either generally or in a particular instance, either retroactively or
prospectively and either for a specified period of time or indefinitely) or
this
Agreement may be amended. Neither this Agreement nor any provisions hereof
may
be changed, waived, discharged or terminated orally, but only by a signed
statement in writing.
6.2 Governing
Law.
This
agreement shall be governed in all respects by the laws of the State of
Delaware, without regard to conflict of laws rules.
6.3 Survival.
The
representations, warranties, covenants and agreements made herein shall survive
each Closing.
6.4 Titles
and Subtitles.
The
titles of the sections of this Agreement are for convenience of reference only
and are not to be considered in construing this Agreement.
6.5 Assignment.
This
Agreement shall be binding upon the Company, the Investor and their respective
heirs, executors, administrators, assigns and legal
representatives.
6.6 Entire
Agreement.
This
Agreement contains the entire understanding of the parties hereto with respect
to the subject matter hereof, and supersedes all other agreements between or
among any of the parties with respect to the subject matter hereof.
6.7 Notices.
All
notices and other communications required or permitted hereunder shall be in
writing and may be delivered in person or by facsimile, electronic mail, courier
or U.S. mail, in which event it may be mailed by first-class, certified or
registered, postage prepaid, addressed (a) if to the Investor, at the address
set forth on the signature page of this Agreement, or at such other address
as
the Investor shall, from time to time, designate to the Company in writing
or
(b) if to the Company, at such address set forth on the signature page of this
Agreement, or at such other address as the Company shall have furnished to
the
Investor in writing. All such notices and other communications shall be deemed
given upon personal delivery, upon confirmation of facsimile transfer, upon
confirmation of electronic mail transmission, upon delivery by courier or three
business days after deposit in the United States mail. Notwithstanding the
foregoing, all notices and communications to addresses outside the United States
shall be given by facsimile and confirmed in writing sent by overnight or
two-day courier service.
6.8 Severability.
In the
event one or more of the provisions of this Agreement should, for any reason,
be
held to be invalid, illegal or unenforceable in any respect, such invalidity,
illegality or unenforceability shall not affect any other provisions of this
Agreement and this Agreement shall be construed as if such invalid, illegal
or
unenforceable provision had never been contained herein.
6.9 Expenses.
The
Company and the Investor shall each bear their own expenses incurred with
respect to this transaction.
6.10 Counterparts.
This
Agreement may be executed in two or more counterparts, each of which shall
be
deemed an original, but all of which together shall constitute one and the
same
instrument.
6.11 Telecopy
Execution and Delivery.
A
facsimile, telecopy or other reproduction of this Agreement may be executed
by
one or more parties hereto, and an executed copy of this Agreement may be
delivered by one or more parties hereto by facsimile or similar electronic
transmission device pursuant to which the signature of or on behalf of such
party can be seen, and such execution and delivery shall be considered valid,
binding and effective for all purposes. At the request of any party hereto,
all
parties hereto agree to execute an original of this Agreement as well as any
facsimile, telecopy or other reproduction hereof.
[Signature
Page Follows]
IN
WITNESS WHEREOF, the parties have executed this Agreement on the day, month
and
year first set forth above.
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COMPANY:
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ADVAXIS,
INC.
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By:
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Name:
Fred Cobb
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Title:
Vice President Finance
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Address:
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Technology
Centre of New Jersey
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675
Rt. 1, Suite B113
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North
Brunswick, N.J. 08902
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Fax:
732-545-1084
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e-mail:cobb@Advaxis.com
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INVESTOR:
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Thomas
A. Moore
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Address:
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Technology
Centre of New Jersey
675
Rt. 1, Suite B113
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North
Brunswick, N.J. 08902
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Fax:
732-545-1084
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e-mail:
moore@advaxis.com
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Exhibit
99.1
ADVAXIS
INCORPORATED’S BOARD OF DIRECTORS
APPROVE
SENIOR PROMISSORY NOTE
Company
Chairman & CEO Thomas Moore To Extend Bridge Loan
12%
Annual Interest, Up to $800,000 Principal, Up to 5 Month
Term
North
Brunswick, NJ – September 30, 2008 – The
Board
of Directors of Advaxis
Inc.,
(OTCBB: ADXS),
a
developmental biotechnology company, has approved, by majority vote, the motion
to accept a senior promissory note (the “Note”) from Advaxis Chairman & CEO
Thomas Moore. Following are the terms of the Note:
|
o
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Principal:
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US$800,000
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o
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Interest:
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12%
Annual Interest`
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|
o
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Instrument:
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Senior
Promissory Note
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o
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Payable:
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February
15 or the completion of at least US$5.0 million funding
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o
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Warrants:
|
1
for every dollar drawn down and issued at the price/terms per share
of the
next raise
|
“The
survival and furtherance of this science is paramount,” commented Advaxis,
Incorporated Chairman and CEO Thomas (“Tom”) Moore. “Irrespective of the
tumultuous market conditions in recent days, my commitment to Advaxis remains
steadfast. In the next few months, we will wrap up additional funding and
continue our trailblazing efforts in cancer treatment with Lovaxin C for the
treatment of cervical cancer.”
As
of
September 29, 2008 US$235,000 had been drawn off this line of
credit.
For
more
information on the Note, please view our most recent 8-K filing on the US
Securities and Exchange Commission’s website, http://www.sec.gov.
About
Advaxis, Inc.
Based
in
North Brunswick, New Jersey, Advaxis is developing proprietary Listeria monocytogenes
(“Lm”)
cancer vaccines based on technology developed by Dr. Yvonne Paterson, Professor
of Microbiology at the University of Pennsylvania and Chairperson of Advaxis’
Scientific Advisory Board. Advaxis is developing therapeutic cancer vaccines
that enhance the immune system’s cancer fighting abilities through its
proprietary Lm based system, which utilizes multiple simultaneous immunological
mechanisms and which has been safely administered to patients with cancer.
Advaxis’
lead Listeria
vaccine
candidate, Lovaxin C, targets HPV-associated cancers such as cervical and head
and neck. Current Lm vaccines in development target prostate, breast, ovarian
and other cancers. Recently, Advaxis completed a Phase I clinical trial of
Lovaxin C. A Phase II clinical trial is planned for patients with cervical
intraepithelial neoplasia (“CIN”). The company intends to start this study in
CIN 2/3 patients in the fall of 2008. The Lm platform also has applications
in
the fields of infectious disease and autoimmune disorders.
For
further information on the Company, please visit: http://www.advaxis.com.
About
Lovaxin C Vaccine
Advaxis’
Listeria technology platform uses modified Listeria monocytogenes to deliver
a
tumor-specific antigen fusion protein. Bioengineered Listeria
that are
attenuated and secrete Advaxis’ proprietary fusion protein, have the ability to
generate a robust immune response, break immune tolerance to cancer and produce
an unusually strong and effective multi-level therapeutic immune response to
existing cancer and other diseases.
Advaxis’
Listeria-based
technology is based on over a decade’s worth of work by Dr. Yvonne Paterson in
her laboratory at the University of Pennsylvania. The Company’s proprietary
antigen fusion protein technology, stimulates innate immunity, both arms of
the
adaptive cellular immune system, suppresses regulatory T cells that inhibit
many
vaccines in the function of activated tumor-killing cells and has other
anti-tumor effects.
Unlike
prophylactic vaccines, Lovaxin C was designed to treat women who have already
developed cervical cancer as a result of contracting a human papilloma virus
(“HPV”) infection, which is the most prevalent sexually transmitted disease in
the US. Current products on the market are ineffective in treating HPV-infected
women.
For
further information on Lovaxin C, please visit: http://www.advaxis.com/lc.htm
Forward-Looking
Statements
Certain
statements contained in this press release are forward-looking statements that
involve risks and uncertainties. The statements contained herein that are not
purely historical are forward looking statements within the meaning of Section
27A of the Securities Act of 1933, as amended and Section 21E of the Securities
Exchange Act of 1934, as amended. Forward-looking statements deal with the
Company’s current plans, intentions, beliefs and expectations and statements of
future economic performance. Forward-looking statements involve known and
unknown risks and uncertainties that may cause the Company's actual results
in
future periods to differ materially from what is currently anticipated. Factors
that could cause or contribute to such differences include those discussed
from
time to time in reports filed by the Company with the Securities and Exchange
Commission. The Company cannot guarantee its future results, levels of activity,
performance or achievements.
Contacts:
The
Investor Relations Group
212-825-3210
Investor
Relations
Conrad
F.
Mir
conrad@investorrelationsgroup.com
Christine
Berni
christine@investorrelationsgroup.com
Public
& Media Relations
Janet
Vasquez
janet@investorrelationsgroup.com
Laura
Colontrelle
laura@investorrelationsgroup.com
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