UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
 
FORM 8-K/A

CURRENT REPORT
Pursuant to Section 13 OR 15(d) of
The Securities Exchange Act of 1934

Date of Report (Date of earliest event reported) March 7, 2006

 
Advaxis, Inc.
(Exact name of registrant as specified in its charter)

 
Colorado
 
00028489  
 
84 - 1521955
(State or other jurisdiction of incorporation)
(Commission File Number)
(IRS Employer Identification No.)

Technology Center of New Jersey
675 Route 1, Suite 119, North Brunswick, New Jersey
 
08902
(Address of principal executive offices)
(Zip Code)

Registrant’s telephone number, including area code (201) 750-2347
(Former name or former address, if changed since last report.)
 
Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions (see General Instruction A.2. below):
 
o
Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)
 
 
o
Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)
 
 
o
Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))
 
 
o
Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))
 


Item 8.01.  Other Events

See Registrant’s press release attached hereto as Exhibit 99.1. for information as to the receipt of approvals from the Ministry of Health of Israel and Ministry of Health of Mexico to conduct in those countries clinical Phase I/II studies as to the safety of its Lovaxin C vaccine which is directed towards the treatment of cervical cancer.

Item 9.01.  Financial Statements and Exhibits


 
a)
Not applicable.
       
 
b)
Not applicable.
       
 
c)
Exhibits
       
   
99.1.
Press Release, dated March 7, 2006
 
2


SIGNATURE

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.


Dated: March 10, 2006
     
  ADVAXIS, INC.
 
 
 
 
 
 
  By:   /s/ Roni Appel
 
Name: Roni Appel
  Title:  Chief Executive Officer
 

3

 
EXHIBIT 99.1


 
Advaxis Inc. Announces Approvals of Israeli and Mexican Regulators to Commence Clinical Study of its Listeria Cancer Vaccine Candidate for Cervical Cancer

North Brunswick, NJ — Advaxis Inc. (OTCBB: ADXS) announced that it has received the approval of the Ministry of Health of Mexico and, subject to the approval of the ethical committee of Hadassah Hospital, the approval of the Ministry of Health of Israel to commence in those countries a Phase I/II trial study of Lovaxin C, a Listeria-based vaccine, directed towards the treatment of cervical cancer. These approvals follow a recently announced approval by the Serbian Agency for Drugs and Medicinal Devices to conduct a study at the Institute for Oncology and Radiology in Belgrade.
 
The study is the first-in-man study by Advaxis in its proposed development of a new class of cancer therapy using Advaxis proprietary delivery system, which uses live Listeria monocytogenes to deliver an antigen fusion protein to generate an immune response characterized by very high levels of tumor infiltrating cytotoxic T cells.
 
This Phase I/II trial of Lovaxin C will be conducted simultaneously at the facility in Belgrade, two facilities in Mexico and, subject to the approval by the Hadassah Hospital ethical committee, at the hospital in Jerusalem, with results expected in the second half of 2006. The company plans to submit the test results to the FDA.
 
About Advaxis
 
Based in North Brunswick, New Jersey. Advaxis is developing proprietary Listeria cancer vaccines based on technology developed by Dr. Yvonne Paterson, professor of microbiology at the University of Pennsylvania, and chairperson of Advaxis' Scientific Advisory Board. Advaxis' is developing therapeutic cancer vaccines that enhance the immune system's cancer-fighting abilities through its proprietary Listeria monocytogenes based system, which utilizes two immunological mechanisms (Innate and Classical Immunity) to develop safer and more effective Listeria based cancer vaccines. Advaxis is the exclusive licensee of a patented broadly enabling Listeria platform technology that can elicit effective anti-tumor responses. Advaxis' lead Listeria vaccine candidate, Lovaxin C, targets cervical and head and neck cancers. Further Listeria vaccines in development target breast, ovarian and lung cancers. Advaxis is entering a Phase I/II clinical trial. The Listeria platform will also have applications in the fields of infectious disease and autoimmune disorders.
 
Forward-Looking Statements
 
Certain statements contained in this press release are forward-looking statements that involve risks and uncertainties. The statements contained herein that are not purely historical are forward looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended and Section 21E of the Securities Exchange Act of 1934, as amended. Forward-looking statements deal with the Company's current plans, intentions, beliefs and expectations and statements of future economic performance. Forward-looking statements involve known and unknown risks and uncertainties that may cause the Company's actual results in future periods to differ materially from what is currently anticipated. Factors that could cause or contribute to such differences include those discussed from time to time in reports filed by the Company with the Securities and Exchange Commission. The Company cannot guarantee its future results, levels of activity, performance or achievements.
 
Company Contact
Advaxis, Inc.
Roni Appel, 201-750-2347 
 
Investor Relations/Public Relations Contact:  
Investor Relations Group
 
Erik Lux/Adam Holdsworth, Investor Relations
Janet Vasquez, Public Relations
212-825-3210
 
1